United States Pharmacopeia, a guide to drug information, which lists some of the side-effects that can 
result from the daily ingestion of the amount of fluoride found in 1 to 2 pints of artificially fluoridated water. 

• Black tarry stools 
• Bloody vomit 
• Faintness 
• Nausea and vomiting 
• Shallow breathing 
• Stomach cramps or pain 
• Tremors 
• Unusual excitement 
• Unusual increase in saliva 
• Watery eyes 
• Weakness 
• Constipation 
• Loss of appetite 
• Pain and aching of bones 
• Skin rash 
• Sores in the mouth and on the lips 
• Stiffness 
• Weight loss 
• White, Brown, or black discoloration of teeth 

The 1983 Physicians’ Desk Reference cautions: "Dental fluorosis may result from exceeding the recommended dose. In hypersensitive individuals, fluorides occasionally cause skin eruptions such as atopic dermatitis, eczema, or urticaria. Gastric distress, headache, and weakness have also been reported. These hypersensitive reactions usually disappear promptly after discontinuation of the fluoride. 

Aging the bone: The degenerative effects of skeletal fluorosis 

Bone also has the ability to rejuvenate itself As older bone is removed by bone scavenger cells called osteoclasts, osteoblasts lay down collagen to produce a framework for new bone formation to renew the skeletal structure. Thus damage to collagen production in bone caninterfere with the normal processes of bone rejuvenation and repair throughout life. 

Fluoride has been shown to interfere with collagen formation in osteoblasts and chondroblas. Increased production of imperfect collagen or collagen-like protein results in mineralization of tissues which should not be mineralized and vice versa, one would expect a calcification of ligaments cartilage and tendons as well as the formation of poorly and overly mineralized bone. This is exactly what happens after exposure to fluoride. 

Hardening of the Arteries
In a number of areas where people consume water containing 3 parts per million fluoride or more, calcification of the arteries has been clinically correlated with the fluoride-induced bone disorders. Fibroblasts in the arterial cell walls are producing larger amounts of an imperfect collagen or collagen-like protein, resulting in hardening of the arteries or arteriosclerosis, the leading cause of death in the United States. 

This is according to Dr. John Negalesko, director of the first year medical program at the Ohio State University Medical School.

Skin

Since collagen is the primary structural material of skin, damage to skin collagen can be expected to lead to the prematurely wrinkled skin. Dr. Wolfgang Klein and co-workers at the Seibersdorf Research Center in Austria reported that 1 part per million fluoride inhibits DNA repair enzyme activity by 50% .Since fluoride inhibits DNA repair enzyme activity, fluoride should also be expected to lead to an increase in genetic or chromosome damage. 

This has indeed been found to occur in numerous studies showing that fluoride in water, even at the concentration of 1 part per million, can cause chromosome damage. 

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